Yes the recent disappearances have made his friendship with George something not just to enjoy but to cling to >.>

He is understandably put off of fishing; there probably aren't any fish anyway!

I would love for Malcolm to start seeing the signs in small ways and also to talk to him about it/help him with it. George is very pragmatic and I can totally see him realizing he can't realistically keep it up before it makes his life completely untenable.

Malcolm did already see him turn to multiple shots of hard liquor to deal with the super bad situation on the island, so that is a good jumping off point for him to notice other situations where George maybe deals by numbing with substances.